Applied Omics & Life Sciences LLC
Public Works
Publications, Patents, and Public Presentations
Patents and Publications
Patents
2018
“Photoactivatable Probes and Uses Thereof”
Publication number: US10067136B1
Filed: February 6, 2017
Publication date: September 4, 2018
Applicants: University of South Florida
Inventors: Roman Manetsch, Arun Babu Kumar, Jeremiah Tipton
2014
“Target Binding Molecules Identified by Kinetic Target-Guided Synthesis”
Publication number: US20160116482A1
Filed: August 6, 2014
Publication date: April 28, 2016
Applicants: THE PENN STATE RESEARCH FOUNDATION, University of South Florida
Inventors: Roman Manetsch, Katya Pavlova Nacheva, David Lawrence Flanigan, Niranjan Kumar Namelikonda, Iredia David Iyamu, Sameer Shamrao Kulkarni, Megan M. Barber, Jeremiah Dwayne Tipton, Hong-Gang Wang, Kenichiro Doi
Publications
2023
Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach
Katya Nacheva, Sameer S. Kulkarni, Mintesinot Kassu, David Flanigan, Andrii Monastyrskyi, Iredia D. Iyamu, Kenichiro Doi, Megan Barber, Niranjan Namelikonda, Jeremiah D. Tipton, Prakash Parvatkar, Hong-Gang Wang, and Roman Manetsch*
J. Med. Chem. 2023, 66, 7, 5196–5207
2016
“3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability”
Kumar, A,B; Tipton, J.D.; Manetsch, R., Chem. Commun. (Camb). 52, 2729-2732 (2016)
2014
“Site-specific human histone H3 methylation stability: fast K4me3 turnover.”
Zheng, Y.; Tipton, J. D.; Thomas, P. M.; Kelleher, N. L. Sweet, S.M.M.
Proteomics 14, (19) 2190–2199, (2014)
2014
“γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation.”
Wu, H.; Li, Y.; Bai, G.; Niu, Y.; Qiao, Q.; Tipton, J.D.; Cao, C.; and Cai, J. Chem. Commun. (Camb). 50, 5206-5208 (2014)
2013
“Light-dependent phosphorylation of Bardet-Biedl syndrome 5 in photoreceptor cells modulates its interaction with arrestin1.”
Smith, T.S.; Spitzbarth, B.; Li J.; Dugger, D.R.; Stern-Schneider, G.; Sehn, E.; Bolch, S.N.; McDowell, J.H.; Tipton, J.; Wolfrum, U.; Smith, W.C.;
Cell Mol Life Sci. 70 (23) 4603 – 4616. (2013)
https://doi.org/10.1007/s00018-013-1403-4
2013
“Oncogene Induced Cellular Senescence Elicits an Anti-Warburg Effect”
Li, M.; Durbin, K.; Sweet, S.S., Tipton, J.D.; Zheng,Y. and Kelleher, N.L.
Proteomics. 13 (17) 2585 – 8596 (2013)
2012
“Total Kinetic Analysis Reveals How Combinatorial Methylation Patterns are Established on Lysines 27 and 36 of Histone H3”
Zheng, Y.; Sweet, S.M.M.; Popovic, R.; Martinez-Garcia, E.; Tipton, J.D.; Thomas, P.M.; Licht, J.D.; and Kelleher, N.L. PNAS, 109 (34) 13549 – 13554 (2012)
2012
”Nano-LC FTICR Tandem Mass Spectrometry for Top-Down Proteomics: Routine Baseline Unit Mass Resolution of Whole Cell Lysate Proteins up to 72 kDa
”Tipton, J.D.; Tran, J.C.; Catherman, A.D.; Ahlf, D.R.; Durbin, K.R.; Lee, J.E.; Kellie, J.F.; Kelleher, N.L.; Hendrickson, C.L.; and Marshall, A.G.
Analytical Chemistry, 84 (5), 2111–2117 (2012)
2012
“High-Throughput, Robust Analysis of the Yeast Proteome <50 kDa Using Molecular Weight-Based Separations and Top Down Mass spectrometry"
Kellie, J.F.; Catherman, A.D.; Durbin, K.R.; Tran, J.C.; Tipton, J.D.; Norris, J.L; Witkowski, C.; Thomas, P.M.; Kelleher, N.L.”,
Analytical Chemistry, 84 (1), 209–215, (2012)
2011
“Mapping Intact Protein Isoforms in Discovery Mode Using Top Down Proteomics”
Tran, J.C.; Zamdborg, L.; Lee, J.E.; Catherman, A.D.; Durbin, K.R.; Ahlf, D.R.; Tipton, J.D.; Vellaichamy, A.; Kellie, J.F.; Li, M.; Wu, C.; Sweet, S.M.; Early, B.P.; Siuti, N.; Compton, P.D.; Thomas, P.M.; Kelleher, N.L.
Nature 480, 254–258, (2011)
2011
“Analysis of Intact Protein Isoforms by Mass Spectrometry”
Tipton, J.D.; Tran, J.C.; Catherman, A.D.; Ahlf, D.R.; Durbin, K.R.; Kelleher, N.L. Journal of Biological Chemistry, 286 (29), 25451-25458, (2011)
2011
Valence Parity to Distinguish c and z● Ions from Electron Capture Dissociation/Electron Transfer Dissociation of Peptides: Effects of Isomers, Isobars, and Proteolysis Specificity” Mao,Y.; Tipton, J.D.; Blakney, G.T.; Hendrickson, C.L.; Marshall, A.G. “ Analytical Chemistry, 83 (20), 8024-8028 (2011)
https://doi.org/10.1021/ac201619t
2010
Chromatographic Reduction of Isobaric and Isomeric Complexity of Fulvic Acids to Enable Multistage Tandem Mass Spectral Characterization.
Capley, E. N.; Tipton, J. D.; Marshall, A. G.; Stenson, A. C.
Analytical chemistry, 82 (19), 8194-202, (2010)
2010
Computing H/D-Exchange Rates of Single Residues from Data of Proteolytic Fragments.” Althaus, E.; Canzar, S.; Ehrler, C.; Emmett, M.R.; Karrenbauer, A.; Marshall, A.G.; Meyer-Bäse, A.; Tipton, J.D.; Zhang, H.M.;
BMC Bioinformatics, 11 (11), 424, (2010)
2010
New Reagents for Enhanced Liquid Chromatographic Separation and Charging of Intact Protein Ions for Electrospray Ionization Mass Spectrometry
Valeja, S.G.; Tipton, J.D.; Emmett, M.R.; Marshall, A.G.
Analytical Chemistry, 82 (17), 7515-7519, (2010)
2010
Sites and Extent of Selenomethionine Incorporation into Recombinant Cas6 Protein by Top-down and Bottom-up Proteomics with 14.5 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Wang, X.; Tipton, J.D.; Emmett, M.R.; Marshall, A.G. Rapid Communications in Mass Spectrometry, 24 (16), 2386-2392, (2010)
2010
Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work and with Transition State Analogues. Edwards, A.A.; Tipton, J.D.; Brenowitz, M.D.; Emmett, M.R. Marshall, A.G; Evans, G.B.; Tyler, P.C.; Schramm, V.L.
Biochemistry, 49 (9), 2058-2067, (2010)
2009
A Robust 2-Dimensional Separation for Top-Down Tandem Mass Spectrometry of the Low Mass Proteome. Lee, J.E.; Kellie, J.F.; Tran, J.C.; Tipton, J.D.; Catherman, A.C.; Thomas, H.M.; Ahlf, D.R.; Durbin, K.R.; Vellaichamy, A.; Ntai, I.; Marshall, A.G.; and Kelleher, N.L. Journal of the American Society for Mass Spectrometry, 20 (12), 2183-2191 (2009)
2009
Sequential Proteolysis and High-Field FTICR MS To Determine Disulfide Connectivity and 4-Maleimide TEMPO Spin-Label Location in L126C GM2 Activator Tipton, J.D.; Carter, J.D.; Mathias, J.D.; Emmett, M.R.; Fanucci, G.E. and Marshall, A.G., Protein. Analytical Chemistry, 81 (18), 7611-7617 (2009)
2008
Enhanced Digestion Efficiency, Peptide Ionization Efficiency, and Sequence Resolution for Protein Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Zhang, H.; Kazazic, S.; Schaub, T.M.; Tipton, J.D.; Emmett, M.R. and Marshall, A.G., Analytical Chemistry, 80 (23), 9034-9041 (2008)
2006
2-Hydroxymethylboronate as a reagent to Detect Carbohydrates: Application to the Analysis of the Formose Reaction
Ricardo, A.; Frye, F.; Carrigan, M.A.; Tipton, J.D.; Powell, D.H.; Benner, S.A. “2-
Journal of Organic Chemistry, 71, 9503-9505 (2006)
1998
Qualitative Analysis of Herbs by Gas, Chromatography/Mass Spectrometry (GC/MS). An Undergraduate Instrumental Analysis Laboratory Exercise
Tipton, J.; Barnicki, T.; Smith, E.T.
The Chemical Educator, 3 (3), 1-12 (1998)